Cloud Cache is useful for creating profile high availability in physical environments. The recommended configuration when using Cloud Cache for physical machines that may go offline (for example, a notebook computer) is:
CCDLocations should be configured so that the first Cloud Cache Provider is placed on the local drive.
ClearCacheOnLogoff would generally be set to 1, to avoid eventually having two full copies of the profile on the local machine.
For more detailed information, see article “Cloud Cache to create resiliency and availability” at https://docs.microsoft.com/en-us/fslogix/cloud-cache-resiliency-availability-cncpt.